Insemination Methods & Outcomes

As a service to our recipients, we make our conception rates available.  We track overall success rates and success rates based on insemination method and recipient age.  The latter information may be especially relevant to TSBC recipients as almost 60% are 35 years or older.  We encourage anyone interested in learning more about age and fertility to read our Conception Strategies.

TSBC Overall Success Rates

We calculate the overall conception rate for our recipients and the rates associated with method of insemination and recipient age. We use five years of data to provide better estimates of the likelihood of conceiving. The most recent analysis is for conception attempts and outcomes from 2012-2017.

Vaginal Insemination & IUI Combined Success Rate: 18.5% per cycle

This rate of 18.5% or almost a 1 in 5 chance in conceiving each cycle attempt matches industry standards for conception through donor insemination. The rate is based on 5099 cycle attempts. It includes (i) all recipients regardless of their age and (ii) all insemination attempts done vaginally, intrauterine, and combined vaginal and intrauterine. Based on an older life table analysis across consecutive cycles, 80% of TSBC recipients conceive within 7 cycle attempts.

 

Success Rate: Insemination Method & Age

 

Using information from all reported conceptions from 2012-2017, we calculated the success rate per cycle attempt according to the recipient's age and method of insemination. In other words, we compared the total number of conceptions resulting for each recipient age group based on their insemination method to the total number of attempts by each age group by insemination method. From this, we then calculated a percent success rate per cycle attempt for each insemination method dependent on recipient age (see Figure).

 

 

 

 

 

 

Based on these data

  • Vaginal inseminations work better among younger recipients.
  • IUI tends to be more successful than vaginal insemination.
  • Success rate is related to a recipient's age: As you get older, the probability of conceiving decreases. Nevertheless, IUI still results in reasonable success rates, with women ages 40-42 (subgroup of age 40-44) on average experiencing a 1 in 10 probability of conceiving in a given cycle attempt.

Notes on the Analysis

  • Vaginal inseminations: The sample of recipients who did vaginal inseminations varied in whether they did one or two inseminations per cycle. Two inseminations were weakly associated with a better success rate.
  • IUIs: Our sample included recipients who did one IUI in a cycle attempt and those who did more than one. We were unable to make direct comparisons, due to an unequal distribution of recipients using fertility drugs across the two groups.
  • Recipients under age 30:  Our sample included too few recipients to calculate a success rate. Fertility studies indicate, however, that this age group has the highest chance of conceiving in a cycle attempt.
  • Recipients over age 44: In our sample, no live births were reported for this age group when they used vaginal insemination alone.
  • Given that fertility is so closely tied to recipient age, anyone age 35+ should read our Conception Strategies.

Conclusions

Our results match findings from the fertility industry and are consistent with clinical research indicating that IUI tends to be more effective than vaginal insemination. Because vaginal insemination is less intrusive and easier to do at home, some may want to try this method first. But if you are age 35+ and have age-related time constraints, we urge you to consider using IUI. Overall, based on these and early analyses, recipients can expect to inseminate for four to eight cycles before conceiving.